PLoS ONE has a article this month titled The Phylogeny of the Four Pan-American mtDNA Haplogroups: Implications for Evolutionary and Disease Studies. There are several points of interest:
- The authors make use of data that is publicly available, either through GenBank or other DNA databases.
- Complete mtDNA sequences (ie., all 16568 bases) were used for phylogenetic reconstruction.
- Among 265 “novel” mtDNA sequences reported among Hispanics and African Americans in a recent addition to GenBank, 101 were of Native American origin.
- All four Native American founder lineages (A2, B2, C1, D1) date to between 18,000-24,000 years ago.
Their results suggest that human expansion into the Americas coincided with the decline of the Last Glacial Maximum (Ice Age), knocking another hole in the “Clovis-first” hypothesis. Given that all four lineages give similar coalescent times, this study may also contribute to the “waves of migration” debate.
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Achilli A, Perego UA, Bravi CM, Coble MD, Kong QP, et al. (2008) The Phylogeny of the Four Pan-American MtDNA Haplogroups: Implications for Evolutionary and Disease Studies. PLoS ONE 3(3): e1764 doi:10.1371/journal.pone.0001764